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Doxycycline and lactic acid bacillus capsule extract with ascorbic acid (Ascorbic Acid) for 3 months.[12] Appears to be safe but requires caution due to anti-biotic side effect.[12] In an open trial, 20 persons with atorvastatin generic online type 1 diabetes who took 60mg/kg and 500mg/kg of acetyl-l-carnitine, butylated hydroxytoluene, and l-ascorbic acid twice daily for two months noted reduced body weight increase with acetyl-l-carnitine but a similar increase with butylated hydroxytoluene and l-ascorbic acid, as well a reduction in blood glucose, LDL, total, and HDL cholesterol, a transient reduction in the number of blood cells with no other changes in these parameters.[12] In another study using 100 mg/kg/day for one month, there were increases in lean body mass (8.55+/-1.42kg placebo, and 10.35+/-2.56kg in acetyl-l-carnitine; p<0.05) but no changes to body water or lean mass after six months.[13] 1.2. Interventions A pilot study in persons with diabetes which Cloridrato de bupropiona 150mg generico were given either acetyl-l-carnitine (50mg) alone or (100mM), butylated hydroxytoluene (300ug), and l-ascorbic acid (200mg) was conducted to assess safety and tolerability after three months of treatment.[14] The main finding was that, although there were statistically significant improvements in serum glucose and cholesterol from both groups (despite statistically significant improvement in blood pressure the acetyl-l-carnitine group, it did not reach statistical significance), there was no significant difference between the groups in terms of liver function or blood cell numbers number of red blood cells.[14] The results of study have not been replicated in a second trial.[15] In a study conducted persons with type 1 diabetes in which persons took acetyl-l-carnitine (50mg) for one month was conducted to assess safety and tolerability after three months of treatment, and the results this study have not been replicated.[14] In persons with Type 1 Diabetes who are on insulin, acetyl-l-carnitine is considered a promising supplement and appears to provide benefits while simultaneously reducing the side effects associated with low blood glucose, although further studies are needed to determine the efficacy of this supplement. 3 Fat Mass 3.1. Adipose Tissue A study on 14 healthy males given 600mg acetyl-l-carnitine (as acetyl-l-carnitine) daily between four to six hours prior exercise (6 sessions per week at 80% of the participants' peak power output) noted that, although there was a benefit in cardiovascular parameters (namely, cardiac output) following exercise, there was no significant effect on fat mass at the end of study (although authors attributed that to the placebo effect and not acetyl-l-carnitine).[16] Another study using 600mg acetyl-l-carnitine for four weeks in men with dyslipidemia (but not hypothyroidism) noted that, despite a decrease in LDL cholesterol, total and an increase in HDL cholesterol relative to placebo, there were no significant changes in fat mass, overall or free mass.[17] One study using an oral formulation of 600mg for 14 days in men with type 2 diabetes (but not hypothyroidism) noted that while there was improvement in LDL cholesterol, there was not any impact on total cholesterol, HDL and triglycerides.[18] In a study using acetyl-l-carnitine (600mg thrice daily) in subjects with type 2 diabetes for four weeks, it was noted that there did not appear to be a significant increase in insulin, total and LDL cholesterol, as well an insignificant increase in HDL-C.[19] 3.2. Liver One study using acetyl-l-carnitine (600mg thrice daily) in patients with cirrhosis noted that while there was evidence indicating that acetyl-l-carnitine may have an anti-oxidant effect, it failed to reach statistical significance.[21] Another study using 250mg daily for one month (as acetyl-l-carnitine but with the content restricted to first two weeks) in persons with Type 1 Diabetes found that there was no significant effect on liver fat or fibrosis when compared to placebo;

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